Corpus GrippeCanadaV3

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Assessing the impact of confounding (measured and unmeasured) in a case-control study to examine the increased risk of pandemic A/H1N1 associated with receipt of the 2008-9 seasonal influenza vaccine.

Identifieur interne : 000547 ( Main/Exploration ); précédent : 000546; suivant : 000548

Assessing the impact of confounding (measured and unmeasured) in a case-control study to examine the increased risk of pandemic A/H1N1 associated with receipt of the 2008-9 seasonal influenza vaccine.

Auteurs : Laura C. Rosella [Canada] ; Rolf H H. Groenwold ; Natasha S. Crowcroft

Source :

RBID : pubmed:22001885

Descripteurs français

English descriptors

Abstract

BACKGROUND

This study examines the role of measured and unmeasured confounding in the relationship between the 2008-9 seasonal influenza vaccine and pandemic H1N1 (pH1N1) influenza virus.

METHODS

Data were taken from a test-negative case-control study of 462 lab confirmed pandemic A/H1N1 (pH1N1) cases and 484 test-negative controls. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were derived using multivariate logistic regression. The analysis was repeated using propensity matching. A sensitivity analysis was conducted to quantify the impact of a hypothetical unmeasured confounder.

RESULTS

Cases were more likely to have received the seasonal influenza vaccine after adjusting for multiple confounders using multivariate regression (OR 1.82, 95% CI: 1.25-2.65), using propensity matching (OR 1.86, 95% CI: 1.19-2.92) and in subsequent sensitivity analyses. An unmeasured confounder would need a prevalence of 20%, an odds ratio with the vaccine and pH1N1 of ≥3.5 and ≥3.0 (respectively) to result in a non-significant association. Using a prevalence of 40% the respective associations were 3.0 and 2.5.

CONCLUSION

A significant positive association between the seasonal influenza vaccine and lab confirmed pH1N1 was observed after considering multiple confounders and using different methods for confounder adjustment. This was not likely explained by an unmeasured confounder given the prevalence and strength of association needed to result in a non-significant association.


DOI: 10.1016/j.vaccine.2011.09.132
PubMed: 22001885


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Assessing the impact of confounding (measured and unmeasured) in a case-control study to examine the increased risk of pandemic A/H1N1 associated with receipt of the 2008-9 seasonal influenza vaccine.</title>
<author>
<name sortKey="Rosella, Laura C" sort="Rosella, Laura C" uniqKey="Rosella L" first="Laura C" last="Rosella">Laura C. Rosella</name>
<affiliation wicri:level="1">
<nlm:affiliation>Public Health Ontario, Toronto, Ontario, Canada. laura.rosella@oahpp.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Public Health Ontario, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Groenwold, Rolf H H" sort="Groenwold, Rolf H H" uniqKey="Groenwold R" first="Rolf H H" last="Groenwold">Rolf H H. Groenwold</name>
</author>
<author>
<name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:22001885</idno>
<idno type="pmid">22001885</idno>
<idno type="doi">10.1016/j.vaccine.2011.09.132</idno>
<idno type="wicri:Area/Main/Corpus">000488</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000488</idno>
<idno type="wicri:Area/Main/Curation">000488</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000488</idno>
<idno type="wicri:Area/Main/Exploration">000488</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Assessing the impact of confounding (measured and unmeasured) in a case-control study to examine the increased risk of pandemic A/H1N1 associated with receipt of the 2008-9 seasonal influenza vaccine.</title>
<author>
<name sortKey="Rosella, Laura C" sort="Rosella, Laura C" uniqKey="Rosella L" first="Laura C" last="Rosella">Laura C. Rosella</name>
<affiliation wicri:level="1">
<nlm:affiliation>Public Health Ontario, Toronto, Ontario, Canada. laura.rosella@oahpp.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Public Health Ontario, Toronto, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Groenwold, Rolf H H" sort="Groenwold, Rolf H H" uniqKey="Groenwold R" first="Rolf H H" last="Groenwold">Rolf H H. Groenwold</name>
</author>
<author>
<name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name>
</author>
</analytic>
<series>
<title level="j">Vaccine</title>
<idno type="eISSN">1873-2518</idno>
<imprint>
<date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adolescent</term>
<term>Adult</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Confidence Intervals</term>
<term>Confounding Factors, Epidemiologic</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Odds Ratio</term>
<term>Ontario</term>
<term>Pandemics</term>
<term>Risk Factors</term>
<term>Sensitivity and Specificity</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse multivariée</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Intervalles de confiance</term>
<term>Jeune adulte</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Odds ratio</term>
<term>Ontario</term>
<term>Pandémies</term>
<term>Sensibilité et spécificité</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en">
<term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en">
<term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en">
<term>Ontario</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr">
<term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en">
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adolescent</term>
<term>Adult</term>
<term>Case-Control Studies</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Confidence Intervals</term>
<term>Confounding Factors, Epidemiologic</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Odds Ratio</term>
<term>Pandemics</term>
<term>Risk Factors</term>
<term>Sensitivity and Specificity</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse multivariée</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Intervalles de confiance</term>
<term>Jeune adulte</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Odds ratio</term>
<term>Ontario</term>
<term>Pandémies</term>
<term>Sensibilité et spécificité</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>
<b>BACKGROUND</b>
</p>
<p>This study examines the role of measured and unmeasured confounding in the relationship between the 2008-9 seasonal influenza vaccine and pandemic H1N1 (pH1N1) influenza virus.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Data were taken from a test-negative case-control study of 462 lab confirmed pandemic A/H1N1 (pH1N1) cases and 484 test-negative controls. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were derived using multivariate logistic regression. The analysis was repeated using propensity matching. A sensitivity analysis was conducted to quantify the impact of a hypothetical unmeasured confounder.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Cases were more likely to have received the seasonal influenza vaccine after adjusting for multiple confounders using multivariate regression (OR 1.82, 95% CI: 1.25-2.65), using propensity matching (OR 1.86, 95% CI: 1.19-2.92) and in subsequent sensitivity analyses. An unmeasured confounder would need a prevalence of 20%, an odds ratio with the vaccine and pH1N1 of ≥3.5 and ≥3.0 (respectively) to result in a non-significant association. Using a prevalence of 40% the respective associations were 3.0 and 2.5.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>A significant positive association between the seasonal influenza vaccine and lab confirmed pH1N1 was observed after considering multiple confounders and using different methods for confounder adjustment. This was not likely explained by an unmeasured confounder given the prevalence and strength of association needed to result in a non-significant association.</p>
</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">22001885</PMID>
<DateCompleted>
<Year>2012</Year>
<Month>02</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised>
<Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1873-2518</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>29</Volume>
<Issue>49</Issue>
<PubDate>
<Year>2011</Year>
<Month>Nov</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Vaccine</Title>
<ISOAbbreviation>Vaccine</ISOAbbreviation>
</Journal>
<ArticleTitle>Assessing the impact of confounding (measured and unmeasured) in a case-control study to examine the increased risk of pandemic A/H1N1 associated with receipt of the 2008-9 seasonal influenza vaccine.</ArticleTitle>
<Pagination>
<MedlinePgn>9194-200</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2011.09.132</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This study examines the role of measured and unmeasured confounding in the relationship between the 2008-9 seasonal influenza vaccine and pandemic H1N1 (pH1N1) influenza virus.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Data were taken from a test-negative case-control study of 462 lab confirmed pandemic A/H1N1 (pH1N1) cases and 484 test-negative controls. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were derived using multivariate logistic regression. The analysis was repeated using propensity matching. A sensitivity analysis was conducted to quantify the impact of a hypothetical unmeasured confounder.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Cases were more likely to have received the seasonal influenza vaccine after adjusting for multiple confounders using multivariate regression (OR 1.82, 95% CI: 1.25-2.65), using propensity matching (OR 1.86, 95% CI: 1.19-2.92) and in subsequent sensitivity analyses. An unmeasured confounder would need a prevalence of 20%, an odds ratio with the vaccine and pH1N1 of ≥3.5 and ≥3.0 (respectively) to result in a non-significant association. Using a prevalence of 40% the respective associations were 3.0 and 2.5.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">A significant positive association between the seasonal influenza vaccine and lab confirmed pH1N1 was observed after considering multiple confounders and using different methods for confounder adjustment. This was not likely explained by an unmeasured confounder given the prevalence and strength of association needed to result in a non-significant association.</AbstractText>
<CopyrightInformation>Copyright © 2011 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Rosella</LastName>
<ForeName>Laura C</ForeName>
<Initials>LC</Initials>
<AffiliationInfo>
<Affiliation>Public Health Ontario, Toronto, Ontario, Canada. laura.rosella@oahpp.ca</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Groenwold</LastName>
<ForeName>Rolf H H</ForeName>
<Initials>RH</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Crowcroft</LastName>
<ForeName>Natasha S</ForeName>
<Initials>NS</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2011</Year>
<Month>10</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Netherlands</Country>
<MedlineTA>Vaccine</MedlineTA>
<NlmUniqueID>8406899</NlmUniqueID>
<ISSNLinking>0264-410X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList>
<CommentsCorrections RefType="CommentIn">
<RefSource>Vaccine. 2012 Mar 9;30(12):2037-8</RefSource>
<PMID Version="1">22119923</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016001" MajorTopicYN="N">Confidence Intervals</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D015986" MajorTopicYN="Y">Confounding Factors, Epidemiologic</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D009864" MajorTopicYN="N" Type="Geographic">Ontario</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2011</Year>
<Month>07</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2011</Year>
<Month>09</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2011</Year>
<Month>09</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2011</Year>
<Month>10</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2011</Year>
<Month>10</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2012</Year>
<Month>3</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">22001885</ArticleId>
<ArticleId IdType="pii">S0264-410X(11)01589-1</ArticleId>
<ArticleId IdType="doi">10.1016/j.vaccine.2011.09.132</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Canada</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Crowcroft, Natasha S" sort="Crowcroft, Natasha S" uniqKey="Crowcroft N" first="Natasha S" last="Crowcroft">Natasha S. Crowcroft</name>
<name sortKey="Groenwold, Rolf H H" sort="Groenwold, Rolf H H" uniqKey="Groenwold R" first="Rolf H H" last="Groenwold">Rolf H H. Groenwold</name>
</noCountry>
<country name="Canada">
<noRegion>
<name sortKey="Rosella, Laura C" sort="Rosella, Laura C" uniqKey="Rosella L" first="Laura C" last="Rosella">Laura C. Rosella</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/GrippeCanadaV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000547 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000547 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    GrippeCanadaV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:22001885
   |texte=   Assessing the impact of confounding (measured and unmeasured) in a case-control study to examine the increased risk of pandemic A/H1N1 associated with receipt of the 2008-9 seasonal influenza vaccine.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:22001885" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeCanadaV3 

Wicri

This area was generated with Dilib version V0.6.35.
Data generation: Tue Jul 7 13:36:58 2020. Site generation: Sat Sep 26 07:06:42 2020